Bremner LaboratoryLunenfeld-Tanenbaum Research Institute, Sinai Health / University of Toronto
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Publications

Selected research

Work spanning cancer-state classification, oncogenic transformation, functional genomics, retinoblastoma and human retinal development.
2025

Nature

Cell cycle duration determines oncogenic transformation capacity

2023

Cell Reports

Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses

2022

Clinical Cancer Research

Targeting the Ubiquitin-Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer

2022

Cell Reports

An immature, dedifferentiated, and lineage-deconstrained cone precursor origin of N-Myc-initiated retinoblastoma

2021

Cancer Cell

Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity

2021

STAR Protocols

Lentiviral-mediated ectopic expression of YAP and TAZ in YAPoff cancer cell lines

2020

Oncogene

Functional genomics identifies new synergistic therapies for retinoblastoma

2020

Developmental Cell

Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development

2014

Nature

Cancer: The origin of human retinoblastoma

2009

Cell

Retinoblastoma, an inside job

2004

Cancer Cell

Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma