Research
Why do some cells transform—and others resist?
The laboratory searches for organising principles that connect cell identity, cell-cycle behaviour, tumour state, therapeutic response and neural regeneration.
Binary YAP cancer states
We investigate how opposite YAP/TEAD activity divides diverse tumours into two higher-order states with contrasting lineage programmes, behaviours and treatment vulnerabilities.
Cell-cycle duration and transformation
We study why an oncogenic mutation can be harmless in most cells yet transform a specific developmental or lineage context.
Retinoblastoma and retinal regeneration
We use the retina to understand how developmental circuitry creates cancer susceptibility—and how neurons can be protected or encouraged to regenerate.
Functional genomics and therapeutic synergy
We combine systematic perturbation with mechanistic validation to identify genetic dependencies and drug combinations that produce deeper cancer responses.